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Main Outcomes and Measures Patients were interviewed about demographic characteristics, health outcomes, and dog exposure during the 7 days before illness onset. Available records from cases occurring before 2016 with genetically related isolates were also obtained. In conjunction with state and federal partners, the Centers for Disease Control and Prevention investigated cases of culture-confirmed C jejuni infections in US patients with an epidemiologic or molecular association with pet store puppies between January 1, 2016, and February 29, 2020. Objectives To investigate cases of extensively drug-resistant C jejuni associated with pet store puppies and describe the epidemiologic and laboratory characteristics of these infections.ĭesign, Setting, and Participants In August 2017, health officials identified, via survey, patients with C jejuni infections who reported contact with puppies sold by pet stores. Importance Extensively drug-resistant Campylobacter jejuni infections cannot be treated with any commonly recommended antibiotics and pose an increasing public health threat. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.
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Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.An interactive version of this figure is available at. The number of allele differences between isolates is proportionate to the combined distance to the nearest common node the distance corresponding to 100 allele differences is shown. Other shaded rings correspond to the investigation type (innermost ring) isolate type susceptibility status for tetracycline, gentamicin, nalidixic acid, ciprofloxacin, azithromycin, erythromycin, clindamycin, telithromycin, and florfenicol and extensively drug-resistant (XDR) status (outermost ring). Isolate identifications are shaded according to the clade to which they belong. 18 Antibiotic resistance determination was based on antibiotic susceptibility testing results when available (n = 72) and otherwise on the presence of known resistance determinants in the bacterial genome for all agents except florfenicol. Isolate relatedness was assessed using core genome multilocus sequence typing the figure was generated using Interactive Tree of Life software, version 5 (BioByte Solutions).